Chemotherapy for lymphatic filariasis: progress but not perfection.
Identifieur interne : 008F25 ( Main/Exploration ); précédent : 008F24; suivant : 008F26Chemotherapy for lymphatic filariasis: progress but not perfection.
Auteurs : Wayne D. Melrose [Australie]Source :
- Expert review of anti-infective therapy [ 1478-7210 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Wuchereria bancrofti.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Ivermectine.
- Animaux, Association de médicaments, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Ivermectin.
- drug therapy : Elephantiasis, Filarial.
- physiology : Wuchereria bancrofti.
- Animals, Drug Therapy, Combination, Humans.
Abstract
Currently, only three drugs are used to control and treat the mosquito-borne parasitic disease lymphatic filariasis: diethylcarbamazine, ivermectin (Mectizan) and albendazole (Zentel). All interrupt transmission by eliminating microfilaria, the parasite stage that is responsible for transmission between hosts, but do not reliably kill the adult worms that are responsible for much of the pathology seen in the disease. There is an urgent need to develop drugs that will reliably kill adult worms and several compounds are under-going in vitro and animal testing. An alternative strategy - that of targeting symbiont bacteria within the parasite - has also shown promising results.
PubMed: 15482154
Affiliations:
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Melrose</name><affiliation wicri:level="1"><nlm:affiliation>Lymphatic Filariasis Support Center, School of Public Health and Tropical Medicine, James Cook University, Townsville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lymphatic Filariasis Support Center, School of Public Health and Tropical Medicine, James Cook University, Townsville</wicri:regionArea><wicri:noRegion>Townsville</wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of anti-infective therapy</title><idno type="ISSN">1478-7210</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albendazole (therapeutic use)</term><term>Animals</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Humans</term><term>Ivermectin (therapeutic use)</term><term>Wuchereria bancrofti (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Albendazole (usage thérapeutique)</term><term>Animaux</term><term>Association de médicaments</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Ivermectine (usage thérapeutique)</term><term>Wuchereria bancrofti (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term><term>Diéthylcarbamazine</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Currently, only three drugs are used to control and treat the mosquito-borne parasitic disease lymphatic filariasis: diethylcarbamazine, ivermectin (Mectizan) and albendazole (Zentel). All interrupt transmission by eliminating microfilaria, the parasite stage that is responsible for transmission between hosts, but do not reliably kill the adult worms that are responsible for much of the pathology seen in the disease. There is an urgent need to develop drugs that will reliably kill adult worms and several compounds are under-going in vitro and animal testing. An alternative strategy - that of targeting symbiont bacteria within the parasite - has also shown promising results.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Melrose, Wayne D" sort="Melrose, Wayne D" uniqKey="Melrose W" first="Wayne D" last="Melrose">Wayne D. Melrose</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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